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The method of claim 2 wherein the substrate portion has a higher melting point than the dosage form. The advantages of using a pre-manufactured dosage form over an in-line process where the medicated ingredients are applied to the tampon coincident with the tampon manufacturing process are numerous. The dosage form, which includes a therapeutic agent, is solid or semi-solid at room temperature, is sufficiently stable, and may be manufactured separately in a controlled facility, whereby dose is easily controlled through controls on concentration and purity. In a different aspect of the present invention, the tampon body 34 or the pusher 85 may be advanced against a side of the substrate 60 opposite the side on which the dosage form 45 is resident with enough forced to break through the substrate 60 to push the dosage form 45 away from the substrate The user then squeezes the fingergrip ring 28 and pushes the finger flange 32 toward the fingergrip ring 28 to force the second member 18 further into the first member 14 until the dosage form 45 is expelled from the first member In use at body temperature, the excipient may also melt and might tend to absorb further into the tampon body 34 instead of desirably migrating to the vaginal or other epithelium. Vaginally administerd anti-dysrhythmic agents for treating pelvic pain and infertility.

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The tampon 20 commonly has a withdrawal string 36 fastened to the tampon body 34 and extending from the proximal end

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US7993667B2 - Methods of manufacturing a medicated tampon assembly - Google Patents

The invention, however, applies equally to other forms of products, including tampon-like devices and vaginally-inserted devices, and should not be limited to the example described herein. In a different aspect of the present invention, any suitable method of removing the dosage form 45 and a substrate portion 90 from the strip of substrate 60 may be employed. The substrate 60 may be meltable, dissolvable, or chemically reactive. In use at body temperature, the excipient may also melt and might tend to absorb further into the tampon body 34 instead of desirably migrating to the vaginal or other epithelium. Tongue jewelry made from the sauropsid line that led to many ancient and medieval European contexts. SUPPOCIRE suppository base or other semi-synthetic glyceride may be used as a significant excipient component of the dosage form, as well as the primary component of the substrate

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